I Took Psilocybin, Creatine And Cordyceps For 30 Days

For the last month, I’ve been running an experiment on myself. Inspired by the Stamets Stack, but personalised for my goals. While Stamets talks about combining lion’s mane, psilocybin and niacin to support nerve growth and cognitive enhancement, mine is geared toward physical performance.

The stack: 50mg dried psilocybin mushrooms, 5g creatine, and 800mg cordyceps extract (I use these Cordyceps capsules). I take the microdose two days on, one day off. And the other two I take daily.

The results: Much better cardio. Faster recovery. Insane physical and mental energy.

Let me break down why I chose these ingredients in my stack, and my theory as to their effects.

Here’s what I think is happening, broken down from a first principles perspective.

Your cells need ATP. It’s the energy currency that keeps everything running, allowing your muscles, your brain, and your mitochondria to do their thing. When you push hard, you burn through ATP faster than your mitochondria can make it. That’s when you hit the wall and fatigue sets in.

My stack attacks the energy problem from three angles.

Creatine doesn’t make energy. It stores and recycles it.

When your mitochondria can’t produce ATP fast enough, creatine steps in by increasing phosphocreatine stores, which rapidly regenerates ATP. It’s your body’s emergency power supply, buffering energy during high demand and reducing mitochondrial stress.

It’s well established that creatine improves physical performance by increasing ATP availability during high-intensity, explosive exercise, such as weightlifting or sprinting. It has been shown to enhance strength, increase muscle mass, improves recovery between sets, and possibly help prevent injury.

A massive new review published in Advances in Nutrition confirms that creatine isn’t just for muscles. It’s neuroprotective, it improves cognitive stamina, and it reduces mental fatigue over time.

It has this effect because your brain is one of the highest ATP-demanding tissues in your body. When you give it an energy buffer, you’re protecting against the energy deficits that underlie brain fog, ageing, and neurodegeneration.

While creatine works at the end of the energy chain (recycling ATP), cordyceps works at the beginning by improving how your mitochondria actually produce ATP in the first place.

Cordyceps mushroom contains cordycepin and adenosine analogues that optimise your electron transport chain, improve oxygen utilisation, and increase ATP production capacity. Translation for us regular folk: you make more energy, more efficiently, with less oxidative stress.

Recent research published in Frontiers in Pharmacology and Scientific Reports shows cordyceps improves VO₂ max and endurance metabolism. This means you breathe easier during effort, energy feels sustained rather than spiky, and you don’t crash.

Here’s the fun part.

Most people think of psilocybin as something that acts on serotonin receptors and shifts perspective. But research over the last year suggests something deeper: psilocybin appears to have profound effects on metabolic health.

A study in Molecular Metabolism published this year (and that I reported on here) showed that microdoses of psilocybin reversed metabolic disease in mice. Not improved. Reversed.

Earlier research showed it extends cellular lifespan and improves overall health in rats. And Bryan Johnson’s N=1 experiment suggested it can essentially reset metabolism. What’s emerging is a picture of psilocybin as a metabolic regulator, potentially improving mitochondrial function, reducing inflammation, and enhancing cellular resilience.

We don’t fully understand the mechanism yet. But if you’re thinking about brain energy, mitochondrial health, and cellular regeneration, psilocybin isn’t just a cognitive tool anymore. It looks like it might be more of a metabolic one.

So, let’s think about what actually causes fatigue, brain fog, poor recovery, etc.

At the cellular level, it’s almost always an energy crisis. Your mitochondria just can’t keep up. ATP demand is exceeding supply. Oxidative stress is accumulating from inefficient energy production.

My stack addresses that crisis from three directions:

One increases flow. One builds storage. One tunes the whole system.

The result is higher output, lower fatigue, less mitochondrial stress, and better brain energy. It’s making your cells more resilient to the demands you place on them.

Subjectively, I like I’m brimming with energy. My cardio capacity in football is noticeably better. Recovery between games is faster. And during the week when working, there’s a sustained mental clarity that feels different from the sharper, more immediate effect of the Stamets Stack.

It feels like my baseline has shifted. I plan to go a few weeks without taking the stack and see if the benefits remain.

If you’re into strength training, brain optimisation, or dealing with brain fog, then start with creatine. It’s the most immediate and well-researched.

If you’re doing cardio, struggling with breathlessness, or fighting chronic fatigue, then cordyceps is worth a try. It works upstream, improving how your body uses oxygen and produces energy.

If you’re a bit older (say 30+) and thinking about longevity and long term health, then consider both.

And if you’re already living a healthy lifestyle and are interested in ancient fungal compounds, human physiology, and cutting-edge metabolic research, then try adding psilocybin microdoses to the mix (if it’s legal where you live, of course.)

I take them all in the morning.

I’m also considering adding taurine to this as it supports mitochondrial function and has anti-inflammatory effects that might complement the stack. But that’s for next month’s experiment.

What’s your stack? Have you tried anything similar? What’s your approach to cellular energy and performance? I’d genuinely love to hear what’s working for other people. This feels like the edge of something important, or maybe I’m just getting a bit carried away. Either way it’s working for me.

Disclaimer: This is not medical advice and I do not encourage anyone to break the law. Please do your own research. I am not a doctor and may well be considered an idiot.