It's been a big week for the business side of psychedelics, the science of an underrated mushroom compound, and one very unconventional pre-workout. Here's everything from the past seven days. 🌱
🔬 LEAD STORY
Is LSD Really Better Than Psilocybin for Depression? What Definium's Phase 3 Data Actually Shows
On Monday, Definium Therapeutics (formerly MindMed) saw its shares jump more than 50% after reporting that DT120, its LSD-based depression treatment, hit every primary and key secondary endpoint in its 149-patient Emerge trial. The company's CEO told Fierce Biotech the data was "the best ever seen in a pivotal study of depression."
That's a big claim. We dig into what the Phase 3 data actually shows, how it stacks up against psilocybin's own trial results, and whether the comparison between the two compounds is even the right question to be asking.
→ Read the full breakdown: https://thesporereport.com/is-lsd-really-better-than-psilocybin-for-depression-what-definiums-phase-3-data-actually-shows/
📰 THIS WEEK'S STORIES
🎪 June 29 · Events · Culture
Inside the UK's First Dedicated Mushroom Festival: All Things Fungi
If you've ever wished there was a festival that took mushrooms as seriously as it takes live music, your wish has been granted. The All Things Fungi Festival returns to West Sussex this September, and it's shaping up to be the best celebration of Kingdom Fungi the UK has seen. Tickets are available through the festival’s official tickets page, with a published lineup that organisers note may shift as the date gets closer.
I’ll be there, so if you’re going, please come and say hi!!!
→ Read the full story: https://thesporereport.com/inside-the-uks-first-dedicated-mushroom-festival-all-things-fungi/
🧠 June 25 · Cohort Study · Brain Health
A Compound Almost Exclusively Found in Mushrooms Just Outperformed Every Other Molecule in a Massive Brain Health Study
A new study in Nature Aging screened almost a thousand different molecules in the blood of over a thousand middle-aged people, none of whom had dementia. Higher levels of one stood out above all the rest: ergothioneine, a compound almost exclusively found in mushrooms, linked to better brain function and a lower risk of Alzheimer's. And almost nobody is getting enough of it.
→ Read the full story: https://thesporereport.com/higher-levels-of-this-one-mushroom-compound-predicted-better-memory-in-a-study-of-over-a-thousand-people-and-almost-nobody-is-getting-enough-of-it/
💪 June 24 · Personal Essay · Performance
Could Psilocybin Mushrooms Be The Ultimate Pre-Workout?
A personal account of stumbling onto an unconventional pre-workout — not caffeine, not an electrolyte sachet, not an eleven-ingredient powder blend. The OG pre-workout your hunter-gatherer ancestors used to tune into the patterns of the forest and drop into flow.
→ Read the full story: https://thesporereport.com/could-psilocybin-mushrooms-be-the-ultimate-pre-workout/
🦠 June 23 · Research · Immune System
Magic Mushrooms Might Be Rewiring Your Immune System
One of the strangest things about psilocybin therapy is the mismatch in timing: the drug clears the body within hours, but the benefits can last for weeks or months. A new study suggests the strongest signal behind that lasting effect isn't in the brain at all — it's in the immune system.
→ Read the full story: https://thesporereport.com/this-new-study-on-psilocybin-and-addiction-recovery-found-the-strongest-signal-wasnt-in-the-brain-it-was-in-the-immune-system/
🍄 WANT TO EXPLORE THE MEDICINE?
Whether you're curious about microdosing or growing your own, here are the most trusted options we've found — vetted and used by our community.
Functional mushrooms
🇬🇧 UK — Mushies · 10% off your first order with code THANKYOU
Microdosing (pre-made)
🇺🇸 US — Serenite Labs · 10% off with code MUSHIES
🇪🇺 EU — Go-Microdose · 10% off with code MUSHIES10
Grow your own (magic mushroom kits)
🚀 Martian Mushrooms (UK/EU) — easy, fast, beginner-friendly
🌍 Spore Buddies (UK/EU) — the world's only auto-fruiting, fully sealed grow bag · 10% off with code CANNADO10
Retreats
Beckley Retreats are the gold standard — backed by 25+ years of research. Our community gets $500 / £375 off with code BRAP-MUSHIESUK
⚠️ Spores and grow kits are sold for microscopy and research purposes. Growing psilocybin mushrooms remains illegal in the UK and many other countries. Please check your local laws.